In a study of six different mental disorders and a thousand brain regions, a team of researchers from Monash University in Australia has uncovered heterogeneous, person-specific differences between individuals within each disorder. This may be one reason why therapies such as non-invasive brain stimulation to treat depression are effective in only one-third of patients.

Using a novel approach of imaging and high-resolution functional magnetic resonance imaging (fMRI), neuroscientists and physicists from MPI CBS in Leipzig, Germany, together with neuroanatomist Menno Witter from the Kavli Institute for Systems Neuroscience in Trondheim, Norway, have explored the human memory system.

Drafts updating the EU Chemicals Regulation indicate that the number of animal tests for safety assessment will rise sharply in the coming years. A new study confirms this and shows that the originally expected number of four million animals has already been exceeded.

Humain Award 2023

Wednesday, 19 July 2023 14:45

Together with the Swiss company InSphero, the Physicians Committee for Responsible Medicine (PCRM) will present the HUMAIN Award to five laboratories. Goal is to expand access to human-specific non-animal approaches and accelerate their adoption.

The Joint Research Center of the European Union (JRC) and the European Partnership for Alternatives to Animal testing (EPAA) recently held an informational webinar on their designathon for the use of human-specific methods in systemic toxicity.

A research group led by Prof. Dr. Anne Spang of the Biozentrum of the University of Basel has investigated the lipid metabolism process in yeast cells and human cells. The team found that a protein called Arf1 influences when and how much stored fat is converted into energy.

To analyze malaria disease mechanisms and explore better treatment options, Hesperos, a company based in Orlando, Florida, has developed a malaria disease model on a chip that integrates four human tissue constructs. New treatments are urgently needed because the malaria pathogen has become resistant to drugs. To find new drugs more quickly and effectively, organ-on-a-chip technologies may be well suited.

As published online in Nature in late June, a study suggests that although the beginnings of multiple sclerosis are based on autoimmune disease, the progression of the disease in individual patients depends partly on how well the brain copes with the autoimmune attack.

Adiposity research with cells

Thursday, 06 July 2023 10:25

A team of researchers led by Prof. Dr. Anne Spang from the Biozentrum of the University of Basel has studied the lipid metabolism process in yeast cells and human cells in more detail. They have discovered that the protein Arf1 (ADP-ribosylation factor 1) acts like a molecular switch to regulate how many lipids are converted into ATP in the body.

Scientists at the Wyss Institute at Harvard University in Boston have recreated a model of reflux disease (barrett's disease) in vitro. The goal is to gain a better understanding of the cellular and molecular triggers of this disease and to develop appropriate drug therapies.