Wednesday, 20 September 2023 14:58

Arf1 as a switch point for the degradation of stored fat Featured

A group of researchers led by Prof. Dr. Anne Spang from the Biozentrum at the University of Basel has studied the lipid metabolism process in yeast cells as well as in human cells in more detail. They found that the protein Arf1 ensures that lipids stored in the cells are transported from the lipid droplets to the mitochondria on demand.

Once the energy demand is satisfied, this transport stops again. If the Arf1 protein is missing or overactive, the feedback mechanism is no longer functioning and fatty acids accumulate in the lipid droplets, leading to metabolic disorders.

The researchers now want to identify all the individual proteins involved in the feedback process using proteomics.

The results are published in Nature Cell Biology.
Enkler L, Szentgyörgyi V, Pennauer M, Prescianotto-Baschong C, Riezman I, Wiesyk A, Avraham RE, Spiess M, Zalckvar E, Kucharczyk R, Riezman H, Spang A. Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis. Nat Cell Biol. 2023 Aug;25(8):1157-1172. doi: 10.1038/s41556-023-01180-2. Epub 2023 Jul 3. PMID: 37400497; PMCID: PMC10415182.

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