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Scientists from the University of Veterinary Medicine in Hannover have developed a system to test for development toxicity, with which they want replace rodents. Anstead of rodents they want to use locust embryos.

Together, the Senate Administration for Justice, Consumer Protection and Anti-Discrimination, the State Office for Health and social affairs (LaGeSo) as well as the Association of Research-based Pharmaceutical Companies are announcing the Berlin Prize for the Promotion of Research into Replacement and Supplementary Methods to Animal Experiments. The closing date for applications is 30 September 2019.

BOARDS: Organoids-on-a-Space

Tuesday, 16 July 2019 12:48

Developmental Biology in Space: Scientists from the University of California San Diego led by Alysson R. Muotri, Professor at the UC San Diego School of Medicine, are going to send human brain organoids to the International Space Station ISS. On 21 July it will be start.

3D Model of a human embryo

Tuesday, 16 July 2019 11:32

Scientists from the Institute of Stem Cell Biology and Molecular Embryology at Rockefeller University in New York have made an important step in embryogenesis at a 3-D model of a human embryo.

Scientists from the Florida-based company Hesperos Inc. together with the pharmaceutical company Astra Zeneca, used a multiorgan chip system in order to investigate whether the system can recognize the cardiac toxicity of a drug.

Scientists from the University of California in San Diego (UCSD) have discovered a new genetic variant which is responsible for the defective regulation of blood vessels in the retina during age-related macular degeneration. For their investigations, the researchers developed a retina-on-a-chip model.

An international team of researchers with participation of scientists from the Biocenter of the University of Basel have doubts about the cause of Parkinson's disease. The researchers were able to prove that, in most cases, the Parkinson's characteristic inclusions in the brains' nerve cells do not consist of protein fibrils, but rather of a mixture of membrane fragments. The study published in "Nature Neuroscience" raises new questions about the development of Parkinson's disease.

The 3R Competence Center Switzerland (3RCC) supports six projects with a total of CHF 1.2 millions to promote the 3Rs principle (replacement, reduction and refinement of animal experiments). Among the funded projects is the EAWAG fish cell test.

An international team with participation of the Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo) has established an in vitro/in silico method to predict drug-induced liver injury with regard to oral doses and blood concentrations.  

The start-up company Hesperos, Inc. based in Orlando, Florida, together with the University of Central Florida and the pharmaceutical company Roche has presented a new Body-on-a-Chip model with which both the efficacy of a drug and the toxicity ca be measured in heart and liver as well as in target cells.

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