Tuesday, 22 August 2023 10:08

DyNAtrix: Programmable DNA hydrogels for cell culture and personalized medicine Featured

A team led by Dr. Elisha Krieg of the Institute of Biofunctional Polymer Materials at Leibniz Institute of Polymer Research in Dresden, Germany, has developed a dynamic DNA-crosslinked matrix (called DyNAtrix) by combining classical synthetic polymers with programmable DNA crosslinkers. The new development is of high relevance for in vitro cell culture materials for biological research, according to the current press release.

The stability of DyNAtrix's DNA crosslinks enables controlled adjustment of stress-relaxation properties, mimicking the properties of living tissue. DyNAtrix is self-healing and suitable for 3D printing. The matrix can be degraded in a controlled manner using enzymes.

The work was published in Nature Nanotechnology:
Peng, YH., Hsiao, S.K., Gupta, K. et al. Dynamic matrices with DNA-encoded viscoelasticity for cell and organoid culture. Nat. Nanotechnol. (2023). https://doi.org/10.1038/s41565-023-01483-3

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