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Mouse embryonic stem cells can be grown in the laboratory very well, however this is not possible for human embryonic stem cells. A German-British team of scientists has now discovered human endogenous retrovirus H (HERVH) viruses that play a role at a very early stage of the development of pluripotency.

The days of Alzheimer’s mouse models may be numbered: Researchers at the Harvard Medical School in Boston have developed a three-dimensional human cell culture model using human nerve cells. The aim is to find new useful drugs against the disease.

The scientists Dr. Alexander Mosig and Dr. Knut Rennert from the University Hospital Jena and Prof. Stefan Lorkowski from the Institute of Nutritional Sciences at the University of Jena have been awarded with the this year’s Thuringian Animal Welfare Prize 2014.

Lush Prize Conference 2014

Sunday, 12 October 2014 17:47

On November 14th the LUSH Company is hosting a conference in London. It will be discussed whether the 3R concept (reduce, refine, replace of animal experiments) developed by Russel & Burch in the 1950s “has had its day” or whether the new tox21 concept that entails a total replacement of animals, for instance using pathway-based approaches, is still so far off that 3R will stay relevant for many years to come.

Blind study on in vitro cardiotoxicity

Thursday, 09 October 2014 20:23

Researchers from the German Centre for Cardiovascular Research (DZHK) led by Prof. Thomas Eschenhagen and colleagues from the UK and the Netherlands are going to use artificial heart cells to study whether it is possible to predict side effects of pharmaceuticals on the heart. That way animal experiments could be reduced or fully eliminated.

Jan Lichtenberg and Melanie Aregger from the Swiss company InSphero AG have received the Life Sciences Award from Science|Business, a Belgian-British media association and innovation network. The jury is drawn from academia, industry and venture capital.

Switzerland: Info-Day on Green Toxicology

Monday, 06 October 2014 20:12

On 23 October, Empa Swiss Federal Laboratories for Materials Science and Technology will host an information day on green toxicology in Dübendorf, Switzerland. The registration deadline is the 15th of October.

On 30 September 2014, the Symposium on Alternatives to Animal Testing took place at the Federal Institute for Risk Assessment (BfR) in Berlin, hosted by the State Office of Health and Social Affairs Berlin. What could be heard there was encouraging.

With the help of human cell cultures, a research team from the University of Münster and colleagues from Ulm and Maastricht have gained important insights into the molecular mechanism of the human cytomegalovirus that may lead to the development of arteriosclerosis.

The pharmaceutical computer scientist Dr. Wolfgang Boomgaarden has analysed a wide range of data available on the bioavailability of substances in humans and animals. He found that many drugs that have become commercial success stories, such as Omeprazole, should not normally have been developed at all, because bioavailability in animals, which is required for in the pre-clinical studies, is in fact far too low.