Wednesday, 28 January 2015 22:23

JRC: Using less fish to test chemicals safety Featured

The European Joint Research Center (JRC) has released a new strategy on how to replace, reduce and refine the use of fish in testing of chemicals' effect on flora and fauna in water (aquatic toxicity) and chemicals' uptake and concentration in living organisms (bioaccumulation).

The document will deliver alternative approaches for standard information requirements while ensuring that tests on fish are only conducted as a last resort.

The strategy also proposes the further development of mechanistically-based replacement alternatives, as well as the need to revise existing test guidelines to reduce and refine testing on fish. Concerning bioaccumulation, efforts are encouraged to develop and apply in silico models such as quantitative structure-activity relationships and physiologically based toxicokinetic models, as well as the standardization of in vitro methods for hepatic metabolism in fish.

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