Wednesday, 12 July 2023 14:42

Basel: Arf1 coordinates fatty acid metabolism Featured

A research group led by Prof. Dr. Anne Spang of the Biozentrum of the University of Basel has investigated the lipid metabolism process in yeast cells and human cells. The team found that a protein called Arf1 influences when and how much stored fat is converted into energy.

The protein Arf1 not only has a function in the Golgi apparatus, but Arf1 also controls energy metabolism in the mitochondria. It ensures that lipids are transported from the fat droplets into the mitochondria, the power plants of the cells. There is a feedback function for the termination of this process.

If this process is disturbed or Arf1 is overloaded, fatty acids accumulate in the lipid droplets and no fatty acids in the lipid droplets and no ATP is provided.

Original publication:
Enkler, L., Szentgyörgyi, V., Pennauer, M. et al. Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis. Nat Cell Biol (2023).

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