Tuesday, 09 July 2019 09:29

Parkinson's: Researchers have doubts about the development process Featured

An international team of researchers with participation of scientists from the Biocenter of the University of Basel have doubts about the cause of Parkinson's disease. The researchers were able to prove that, in most cases, the Parkinson's characteristic inclusions in the brains' nerve cells do not consist of protein fibrils, but rather of a mixture of membrane fragments. The study published in "Nature Neuroscience" raises new questions about the development of Parkinson's disease.


Original paper:
Sarah H. Shahmoradian, Amanda J. Lewis, Christel Genoud, Jürgen Hench, Tim E. Moors, Paula P. Navarro, Daniel Castaño-Díez, Gabriel Schweighauser, Alexandra Graff-Meyer, Kenneth N. Goldie, Rosmarie Sütterlin, Evelien Huisman, Angela Ingrassia, Yvonne de Gier, Annemieke J. M. Rozemuller, Jing Wang, Anne De Paepe, Johannes Erny, Andreas Staempfli, Joerg Hoernschemeyer, Frederik Großerüschkamp, Daniel Niedieker, Samir F. El-Mashtoly, Marialuisa Quadri, Wilfred F. J. Van IJcken, Vincenzo Bonifati, Klaus Gerwert, Bernd Bohrmann, Stephan Frank, Markus Britschgi, Henning Stahlberg, Wilma D. J. Van de Berg, and Matthias E. Lauer Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes Nature Neuroscience 22: 1099–1109. doi: 10.1038/s41593-019-0423-2

Source and read more here:
https://www.unibas.ch/