Pain receptors (nociceptors) are specialized peripheral sensory neurons, which are activ during chronic pain conditions caused by chemotherapy, HIV or diabetes.

Traditionally, neuropathic pain research are done with immortalized cell lines, primary human neuronal cells or animal models. However, just
animal models show phenotypic deviations and are time- and cost-intensive. Human cell lines do not display the desired characteristics whereas primary cells are difficult to cultivate.

The company AXOL Bioscience has now developed sensory neuron precursors from human-induced pluripotent stem cells for pain research. The cells possess the necessary functional ion channels, which are an important component of the nociception, the voltage-controlled sodium channels Na v 1.7, Na v 1.8, and Na v 1.9 as well as the transient receptor potential (TRP) ion channels TRPV1, TRPA1 and TRPM8. In tests, the developed cells show a clear pain reaction and hypersensitivity to cold
as a result of administration of hemotherapeutic agents.

Source:
https://www.news-medical.net/whitepaper/20190311/Studying-Chemotherapy-Induced-Neuropathic-Pain-Models-with-iPSC-Derived-Sensory-Neurons.aspx

The brochure about the sensory progenitor cell can be downloaded here:
https://www.axolbio.com/resources?tag=1&type=9#Technical-brochure#Technical-brochure#Technical-brochure