Elderly people and especially post-menopausal women are at increased risk of suffering serious health consequences in response to external stressors such as cancer therapies or infections due to reduced dynamic resilience.

Therefore, for their studies, the scientists will grow white adipose tissue, the liver and lymphoid tissue in organ-on-chip systems and connect the hormone-sensitive organ-like systems to each other via artificial blood vessels.

The cell source material comes from women at different stages of life. In the model, the researchers want to simulate not only hormonal changes but also infections and chemotherapy, and thus compare changes in immune metabolism in response to various stress factors.

The project team includes, in addition to Loskill's µOrganoLab, co-principal investigators Dr. Roser Vento-Tormo from the Wellcome Sanger Institute in Cambridge, UK, Prof. Dr. Stefan Krauss from the University of Oslo and Dr. Nicole Schneiderhan-Marra also from the NMI.


Source and further information:
https://nachrichten.idw-online.de/2023/09/29/weiblicher-resilienz-auf-der-spur-organ-on-chip-technologie-ermoeglicht-neue-einblicke