Lab-on-a-chip systems

Lab-on-a-Chip Systems

Tuesday, 23 June 2015 22:09

On this page you will find publications dealing with tiny cell or organ system developments on microchips. Aim of these developments is to connect all important human organs on the chip with smallest blood vessels to use them for toxicity testing in the future. Therefore this will be reduce or even terminate animal consumption.

The chip systems can also be used in basic research, for instance to study human diseases with appropriate cell or organ systems expressing the disease phenomenon which are apllied to the chip.

The reader is also referred to our news releases and working groups on this topic.


Johan U. Lind, Travis A. Busbee, Alexander D. Valentine et al. (2016): Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Nature Materials.

Frey O., Misun P. M., Fluri D. A., Hengstler J. G. & Hierlemann A. (2014): Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis. Nature Communications 5: 4250. doi: 10.1038/ncomms5250.

K. Schimek, M. Busek, S. Brincker, B. Groth, S. Hoffmann, R. Lauster, G. Lindner, A. Lorenz, U. Menzel, F. Sonntag, H. Walles, U. Marx and R. Horland (2013): Integrating biological vasculature into a multi-organ-chip microsystem; Lab Chip.

E. Materne, A. Tonevitsky and U. Marx (2013): Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput; Lab Chip.

I. Wagner, E. Materne, S. Brincker, U. Süßbier, C. Frädrich, M. Busek, F. Sonntag, D. Sakharov, E. Trushkin, A. Tonevitsky, R. Lauster, U. Marx (2013): A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture; Lab Chip.

B. Ataҫ, I. Wagner, R. Horland, R. Lauster, U. Marx, A. Tonevitsky, A. Azar, G. Lindner (2013): Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion; Lab Chip.

U. Marx, H. Walles, S. Hoffmann, G. Lindner, R. Horland, F. Sonntag, U. Klotzbach, D. Sakharov, A. Tonevitsky, R. Lauster (2012): 'Human-on-a-chip' developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?; Alternatives to Lab Animals.

K.V. Gernaey, F. Baganz, E. Franco-Lara, F. Kensy, U. Krühne, M. Luebberstedt, U. Marx, E. Palmqvist, A. Schmid, F. Schubert, C.F. Mandenius (2012): Monitoring and control of microbioreactors: an expert opinion on development needs; Biotechnology Journal.

R. Horland, G. Lindner, I. Wagner, B. Atac, S. Hoffmann, M. Gruchow, F. Sonntag, U. Klotzbach, R. Lauster, U. Marx (2011): Human hair follicle equivalents in vitro for transplantation and chip-based substance testing; BMC Proceedings.

M. Pilarek, P. Neubauer, U. Marx (2011): Biological cardio-micro-pumps for micro­bio­reactors and analytical micro-systems; Sensors and Actuators.

F. Sonntag, M. Gruchow, I. Wagner, G. Lindner, U. Marx (2011): Miniaturisierte humane organtypische Zell- und Gewebekulturen; BIOspektrum.

F. Sonntag, N. Schilling, K. Mader, M. Gruchow, U. Klotzbach, G. Lindner, R. Horland, I. Wagner, R. Lauster, S. Howitz, S. Hoffmann, U. Marx (2010): Design and prototyping of a chip-besed multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure; Journal of Biotechnology.