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The “Wissenschaftsladen Bonn” (“Science Shop Bonn”), or WiLaBonn for short, is hosting a regular science café with the goal of presenting scientific findings in such a way that the general public can appreciate them. At the café, visitors can mingle with scientists and science journalists in a relaxed atmosphere. Dr. Christiane Hohensee was also invited to take part on 22 September and to answer the questions of 11th and 12th class pupils regarding the possible uses of stem cell research as an alternative to animal experiments.

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) has received a $6 million grant from the National Institutes of Health (NIH) for a consortium to develop a new technological methodology for mapping the molecular pathways of toxicity within cells.

Researchers under the leadership of Preben Boysen from the Norway University of Veterinary Sciences in Oslo have found that laboratory mice raised in a sterilized environments have less killer cells (NK cells) in their immune system than humans or members of the same species raised in the wild. This results is therrefore of particular interest because it shows that scientific results obtained from experiments on mice cannot be reliable transferred to humans.

Stem cells from colon cells isolated and bred

Tuesday, 06 September 2011 21:15

For the first time a research team under the direction of Eduard Batlle from the Institute of Research in Biomedicine (IRB) in Barcelona in cooperation with Hans Clevers from University Medical Center in Utrecht succeeded in finding the site in the colon in which  the stem cells are located.

Scientists from the Helmholtz Centre of Infection Research (HZI) and the Helmholtz Institute of Pharmaceutical Research (HIPS), Saarland, under the direction of Prof. Dr. Claus-Michael Lehr want to convert lung cells from mice into a stable model to investigate the penetration of pathogens (viruses or bacteria) and to test new drugs.

The first Berlin research prize for alternatives to animal experiments has been awarded to Dr. med. Andreas Hocke from the Medical Clinic of Charité Berlin. The jury selected his work on the “Establishment and development of a human lung tissue infection model for reducing and replacing animal experiments in mouse pneumonia models” from ten submissions.

The Head of the Unit “Alternatives to Animal Testing – ZEBET” within the Federal Institute for Risk Assessment (BfR), Dr. Manfred Liebsch, together with Dr. Kevin Crofton of the U.S. Environmental Protection Agency (EPA), has been awarded with this year’s Recognition Award of the Centre for Alternatives to Animal Testing (CAAT).

Until now, it was difficult to artificially create small and complex blood vessels which have to supply nutrients to tissues or tissue-engineered organs. Now, with the Rapid Prototyping method these delicate and complex 3-dimensional models can be produced.

British researchers from Edinburgh under the direction of Tilo Kunath have bred iPS cells – so-called induced pluripotent stem cells - from skin cells of a female patient who suffers from a hereditary form of Parkinsons disease. From these iPS cells they developed dopamine producing nerve cells which showed characteristics of diseased brain cells.

A lung model based on human lung cells and using the Air Liquid Interface (ALI) technique has been tested independently in four German test laboratories. They achieved good and reproducible results which is a first step towards the development of an in vitro replacement method for testing the cytotoxic effects of gases.