Sunday, 29 January 2023 20:03

IUCLID database to avoid animal testing Featured

IUCLID (International Uniform ChemicaL Information Database) is a software application for collecting, storing, maintaining and exchanging data on intrinsic and hazardous properties of chemical substances. Such data play an important role in chemical regulation by both industry and regulatory agencies.

Animal testing in toxicity testing may be avoided by using the category and analogy concept. It is based on using the structural similarity of an output substance to assume the same toxicological property in a target substance, thus fulfilling the information requirements under the Chemicals Regulation. To use this approach, high-quality studies for the endpoint or property under consideration are deposited in databases that registrants can use to access for comparison.

The approach is also appropriate for pharmaceuticals: Just this January, for example, the U.S. Food and Drug Administration (FDA) made available data in the IUCLID database containing results from preclinical animal studies and human data on approved drugs. The data are from repeated-dose toxicity studies, and carcinogenicity, developmental and reproductive toxicology studies.

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