Thursday, 17 February 2022 13:44

Freiburg: Precise tumor metabolism measurement outside the patient's body Featured

A team of scientists led by Dr. Andreas Weltin, Dr. Jochen Kieninger, and Johannes Dornhof from the Institute of Microsystems Engineering (IMTEK) at the University of Freiburg has developed a system that, among other things, makes it possible to study the development of tumor cells outside the human body in a three-dimensional composite. The patients' tumor cells are cultivated in organ chips. Integrated microsensors can measure and control the culture conditions and metabolic rates of the cells at any time.

Organ-on-chip systems with patients' own cells could enable personalized therapies.
Graphic: Johannes Dornhof and Andreas Weltin, IMTEK.

The use of a patient's own stem cells to replicate original tumors in disease models will make it possible in the future to offer personalized therapy outside the body, especially if resistance develops, the researchers explain.

Original publication
Dornhof, J., Kieninger, J., Muralidharan, H., Maurer, J., Urban, G. A., Weltin, A. (2022): Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures. In: Lab on a Chip, 22 (2). DOI: 10.1039/d1lc00689d.

Source and further information: