The model is constructed from the major cell types of the choroid, human melanocytes, retinal pigmented epithelial cells, and microvascular endothelial cells. These cells are integrated into a micro-physiological system simulating the structure of the choroid microvessels. The necessary immune cells are sent through the endothelial channel via tiny channels.
Original publication:
Cipriano, M., Schlünder, K., Probst, C. et al. Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs. Commun Biol 5, 52 (2022). https://doi.org/10.1038/s42003-021-02977-3
Source:
http://www.loskill-lab.com/choroidchip.html