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Scientists at the University of Maine, USA, and colleagues have examined the John Cunningham (JC) virus infection using human primary astrocytes. They found an important signaling pathway, that could provide a clue for potential therapy.

The Center for Alternatives to Animal Testing (CAAT) at the Johns Hopkins Bloomberg School of Public Health is trying to give a home to a scientist at any level of experience who has been displaced from their home institutions due to the Ukraine invasion. Preference is given to the following disciplines: toxicology, artificial intelligence, cheminformatics, bioinformatics, developmental biology, stem cell biology, or neuroscience. However, do not hesitate to contact CAAT with other backgrounds as we administer a number of translational programs.
 

USA: Kidney tissue from the 3D printer

Tuesday, 01 March 2022 10:06

San Diego-based startup Trestle Biotherapeutics has been licensed by Harvard's Office of Technology Development (OTD) to commercialize a suite of stem cell and 3D bioprinting-based regenerative kidney medicine technologies developed at the Harvard Wyss Institute, Harvard John A. Paulson School of Engineering & Applied Sciences (SEAS) and Brigham and Women's Hospital (Brigham).

The European Parliament has welcomed the European Commission's plan To strengthen Europe's fight against cancer, on Feb. 16, 2022, and stressed the importance of animal-free methods.

The state of Baden-Württemberg will continue its proven funding for research into alternative and supplementary methods to animal experiments in 2022.

For the current year, a total of 200,000 euros from the Ministry of Food, Rural Areas, and Consumer Protection is available to fund research into alternative and supplementary methods to animal experiments.

Applications can be submitted until 15 May 2022.

Source:
https://www.baden-wuerttemberg.de/de/service/presse/pressemitteilung/pid/land-foerdert-forschung-zur-vermeidung-von-tierversuchen/

A team of scientists led by Dr. Andreas Weltin, Dr. Jochen Kieninger, and Johannes Dornhof from the Institute of Microsystems Engineering (IMTEK) at the University of Freiburg has developed a system that, among other things, makes it possible to study the development of tumor cells outside the human body in a three-dimensional composite. The patients' tumor cells are cultivated in organ chips. Integrated microsensors can measure and control the culture conditions and metabolic rates of the cells at any time.

In the future, scientists based in Saarland should rely less on animal experiments for the development of new drugs and therapies but instead, use new methods. This was decided by the state parliament on Wednesday, February 16, at the request of the grand coalition.

Involving epilepsy patients with electrodes in the brain, researchers at the Universities of Bonn and Tübingen have discovered that individual neurons are responsible for addition or subtraction during math performance. It did not matter whether the arithmetic task had been posed in symbol or word form.

To better understand the interaction of the organ systems heart and lung and to find new therapeutic options, scientists at the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) in Hannover are conducting research using human disease models.

Using a computer-assisted analysis technique,  scientists from Barcelona have found several natural products that can inhibit an important enzyme of the virus, called protease Mpro. The enzyme plays an important role in the replication of the virus in the host.