Sunday, 21 June 2015 21:15

General criticism of animal experimentation Featured

Alongside ethical arguments, criticism of the use of animal experiments in research is primarily focused on the fact that results cannot be adequately transferred to humans. Well-known examples of this are the medicine pantoprazole or the monoclonal antibody TGN1412.

Information on this subject is frequently an important component of proposals for animal free research projects and of the work conducted by animal protection committees.

The process of searching for publications on the differences between humans and animals is very time consuming, however. For this reason, we have compiled a selection of publications on this subject below.

Choi, Se Hoon ; Kim, Young Hye; Hebisch, Matthias; Sliwinski, Christopher; Lee, Seungkyu; D’Avanzo, Carla; Chen, Hechao; Hooli, Basavaraj; Asselin, Caroline; Muffat, Julien; Klee, Justin B.; Zhang, Can; Wainger, Brian J.; Peitz, Michael; Kovacs, Dora M.; Woolf, Clifford J.; Wagner, Steven L.; Tanzi, Rudolph E. & Kim, Doo Yeon (2014): A three-dimensional human neural cell culture model of Alzheimer’s disease.

Engelhardt, J.A., 2008. Predictivity of animal studies for human injection side reactions with parenteral drug products. Exp. Toxicol. Pathol. 60 (4-5), 323-7.

Hartung, T., 2009. Toxicology for the twenty-first century. Nature 460, 208-212.

Leist, M. & Hartung, T. (2013): Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. Arch. Toxicol. 87: 563-567.

Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W., Dorato, M., Van Deun, K., Smith, P., Berger, B., Heller, A., 2000. Regul. Toxicol. Pharmacol. 32(1), 56-67.

Shanks, N., Greek, R., Greek, J., 2009. Are animal models predictive for humans? Philos. Ethics Humanit. Med. 15, 4:2.

Sistare, F.D., DeGeorge, J.J., 2007. Preclinical Predictors of Clinical Safety: Opportunities for Improvement. Clin. Pharmacol. Ther. 82, 210-214.

-> New: Yarborough M, Bredenoord A, D'Abramo F, Joyce NC, Kimmelman J, Ogbogu U, Sena E, Strech D & Dirnagl U. (2018). The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials. PLoS Biol. 16(6):e2006343. doi: 10.1371/journal.pbio.2006343.




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