The Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University in Baltimore, headed by Prof. Thomas Hartung, has conducted developmental neurotoxicological studies with the widely used serotonin reuptake inhibitor paroxetine, which has so far shown contradictory evidence of its effects on human brain development in animal experiments. For their investigations, the researchers used an organotypic brain model (BrainSpheres) derived from pluripotent human stem cells (iPSC).

With the aim of a joint initiative called BR50, Berlin's extra-university research institutions have joined forces to develop common strategies for research and to develop an exchange with politics and society.

In a research project of the Svendsen Laboratory at the Cedars-Sinai Board of Governors Regenerative Medicine Institute in Los Angeles, scientists have discovered that juvenile Parkinson's disease can be caused by genetic disruption of lysosomal cell cleaning. At the same time, they provided a new in vitro model for such Parkinson's diseases. The researchers have published their findings in Nature Medicine.

Berlin is considered the capital of start-ups. Also from the universities come numerous business start-ups. What economic importance do science-based Spin-offs in the Berlin Metropolitan Region? To illustrate this, eight Berlin-based and two universities from Potsdam are currently conducting a systematic survey on business start-up activities from science.

The European Partnership for Alternative Approaches to Animal Testing (EPAA) supports students and young scientists with outstanding work in the field of alternative approaches for attending a high-profile scientific event.

In this interactive course at a beginning Master’s level, the students will learn the best practices of advanced in vitro models, regulatory aspects, (stem) cell biology and technologies for testing medicine and/or substance safety testing as well as how the results can be validated, translated and implemented into human medicine.

A team from the Max Delbrück Center in Berlin has used human muscle cells to find out how statins affect the development, growth and division of skeletal muscle cells. The results provide an indication for a preventive treatment to avoid side effects.

Berlin: 6th SummerSchool of the BB3R

Friday, 14 February 2020 15:08

For the 6th time, the Berlin-Brandenburg 3R Platform (BB3R) is organizing a graduate college (summer school). Under the heading "Ethical and legal aspects and 3R approaches", doctoral students, postdocs and interested scientists are invited to participate.

Researchers from the Berlin Institute of Health (BIH), from the Charité - Universitätsmedizin Berlin as well as from the University Hospital in Heidelberg have developed a model that enables them to improve the accuracy of the CRISPR/Cas9 gen-scissors.

Engineers headed by Ellen Roche, assistant professor of mechanical engineering at MIT, have developed a bionic "heart". It is a more realistic model for testing of artificial heart valves and other heart devices than experiments on animals.