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An international team of researchers with participation of scientists from the Biocenter of the University of Basel have doubts about the cause of Parkinson's disease. The researchers were able to prove that, in most cases, the Parkinson's characteristic inclusions in the brains' nerve cells do not consist of protein fibrils, but rather of a mixture of membrane fragments. The study published in "Nature Neuroscience" raises new questions about the development of Parkinson's disease.

The 3R Competence Center Switzerland (3RCC) supports six projects with a total of CHF 1.2 millions to promote the 3Rs principle (replacement, reduction and refinement of animal experiments). Among the funded projects is the EAWAG fish cell test.

An international team with participation of the Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo) has established an in vitro/in silico method to predict drug-induced liver injury with regard to oral doses and blood concentrations.  

The start-up company Hesperos, Inc. based in Orlando, Florida, together with the University of Central Florida and the pharmaceutical company Roche has presented a new Body-on-a-Chip model with which both the efficacy of a drug and the toxicity can be measured in heart and liver as well as in target cells.

On 11 July 2019, Dr. Jan van der Valk and other experts will speak about options to replace foetal bovine serum (FBS) in cell culture media.

Robotic fish to replace animal testing

Monday, 17 June 2019 11:28

Over the next three years, scientists at the Otto von Guericke University of Magdeburg will be working on replacing live animals with robotic fish in tests carried out at European hydroelectric power plants.

In the EU project "iPSpine" (Induced pluripotent stem cell-based therapy for spinal regeneration) 20 international scientists want to find new and innovative ways of treating intervertebral disc diseases. A new medical product will be developed and tested. consisting of pluripotent stem cells (iPSC) and intelligent biomaterials. For this purpose, the EU is providing 15 million euros as part of Horizon 2020.

Physicians and lung researchers led by professor Robert Bals, professor Thomas Tschernig as well as the pharmacist professor Claus-Michael Lehr from the Saarland University are examining together in a project on how lung tissue destroyed by COPD can be regenerated.

The start-up company TissUse has introduced the brand name HUMIMIC for its Organ-on-a-Chip models, devices and accessories.

According to analysis of current research results, done by scientists from the Leibniz Research Centre for Working Environment and Human Factors (IfADo) as well as from the University of Cologne, a general replacement of animal experiments with the current in vitro test systems is not yet possible. The authors identify a need for further research and propose a systematic approach based on a roadmap.