Researchers around the world are looking for interventions that slow down brain ageing or mitigate its consequences. The team of researchers in Innsbruck has now succeeded in demonstrating typical ageing processes in so-called brain organoids. For the first time, a human tissue model is now available that makes it possible to observe typical degenerative processes such as oxidative and other age-related damage to DNA as well as reduced mitochondrial activity, reports a recent press release.

The brain organoid model is to be used in follow-up studies to find out more about neuronal ageing. One of the aims is to stimulate cells to artificially rejuvenate themselves.

Source and further information:
University of Innsbruck (2025). A molecular fountain of youth for the brain. 17.02.2025. Online: https://www.uibk.ac.at/de/newsroom/2025/ein-molekularer-jungbrunnen-furs-gehirn/
University of Innsbruck. Edenhofer Lab Genomics, Stem Cell Biology and Regenerative Medicine. http://www.edenhofer-lab.com/