Friday, 18 November 2022 11:51

Developmental neurotoxicity: test battery provides high significance Featured

An international research team involving toxicologists from Constance and Düsseldorf has developed a test battery with human cells that can put an end to animal tests to detect neurotoxic substances.

An international team of researchers led by Prof. Marcel Leist (University of Konstanz) and Prof. Ellen Fritsche (Leibniz Institute for Environmental Medicine Research (IUF) Düsseldorf) has successfully tested their animal-free test battery on 120 substances. The results have shown that the test battery is not only technically implementable but above all possesses a measurement sensitivity that is on a level with animal experiments. Since only human cells are used the significance is higher than that of results from animal experiments.

The findings play an important role in the strategy of using human-relevant data for the assessment of developmental neurotoxicity. This is currently being developed by the European Food Safety Authority (EFSA).

Original publication:
Blum, J. et al. (2022). Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals. Chemosphere; DOI: