Wednesday, 19 October 2022 18:17

Multi-Organ Chip to Investigate Harmful Nanoparticles Featured

Researchers are working on investigating the effects of nanoparticles on the human body using a specially developed in vitro system.

Scientists at the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, the Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Sankt Augustin, the Technical University of Berlin, and the start-up TissUse GmbH are investigating the biological effects of aerosols using an in vitro method they developed together.

The system consists of a multi-organ chip system (Humimic Chip3 by TissUse) in which human tissue samples of the lung and liver are integrated. Four of these multi-organ chips can be fitted into an exposure device called ExpoCube®, developed at the Fraunhofer Institute. Using a sophisticated system of micropumps, heating electronics, aerosol lines, and sensors, the device deposits aerosols or nanoparticles onto the cell samples on the multi-organ chip, simulating the exposure of the human lung.

The system is currently undergoing further optimization.