Based on analyses of related proteins, the researchers succeeded in predicting structural statuses of coronavirus proteins. Sixty-nine percent of the proteins could be assigned functions, including three proteins that mimic necessary body own proteins and five others that interfere with or misappropriate body own processes.
The research findings will help to better understand corona mechanisms and develop more effective therapies.
All structural models are freely available on the Aquaria-COVID website (https://aquaria.ws/covid).
Original publication:
Sean I. O'Donoghue, Andrea Schafferhans, Neblina Sikta, Christian Stolte, Sandeep Kaur, Bosco K. Ho, Stuart Anderson, James B. Procter, Christian Dallago, Nicola Bordin, Matt Adcock, Burkhard Rost (2021). SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms Molecular Systems Biology, Sept. 14, 2021 - DOI: 10.15252/msb.202010079.
Source:
https://www.tum.de/en/about-tum/news/press-releases/details/36913
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Tuesday, 21 September 2021 10:54
Munich: High-throughput AI explains how the SARS Cov-2 virus works Featured
To find out more precisely how the SARS-CoV-2 virus manages to evade immune defenses and replicate in the cells of patients, an international research team involving the Technical University of Munich broke new ground with artificial intelligence. They succeeded in compiling the most comprehensive and detailed overview to date of all the 3D structures of the virus proteins available worldwide. In a database, this information is publicly available for research.
Dr. rer. nat.
Menschen für Tierrechte - Tierversuchsgegner Rheinland-Pfalz e.V.