The test is based on the observation that estrogen-like substances cause the connection of cells in the mammary gland. This makes it easier for breast cancer cells to a crucial step in the spread (metastasis) of tumors. In the E-morph test, a test substance is applied to cultured human breast cancer cells. is added to cultured human breast cancer cells. It is then examined whether the cell contacts loosen as they do under the influence of estrogen.

Future applications of the test include testing chemicals that are already on the market, as well as those that are about to be launched. The test can also be used to develop new drugs, improve diagnostic tests to detect breast cancer, and optimize therapies.

The scientists have presented the test in the journal Environment International.

Kornhuber, M., Dunst, S. Schönfelder, G. & Oelgeschläger, M. (2021). The E-Morph Assay: Identification and characterization of environmental chemicals with estrogenic activity. based on quantitative changes in cell-cell contact organization of breast cancer cells.
Environment International 149: 106411. https://doi.org/10.1016/j.envint.2021.106411

Source:
https://www.bfr.bund.de/de/presseinformation/2021/08/mit_kuenstlicher_intelligenz_dem_brustkrebs_auf_der_spur-267822.html