The researchers around Dr Mijo Simunovic generated a human epiblast, an early multicellular structure during embryogenesis. For this purpose, they triggered an embryogenesis in human embryonic stem cells embedded in a hydrogel. The structure was then exposed to the bone-morphogenetic protein called BMP4 (Bone morphogenetic protein 4), which led to the subsequent formation of the primitive strip.
The scientists hope that they have found a model that can be used to study molecular mechanisms at this early embryonic stage.
The researchers presented their model in the journal Nature Cell Biology:
Mijo Simunovic, Jakob J. Metzger, Fred Etoc, Anna Yoney, Albert Ruzo, Iain Martyn, Gist Croft, Dong Shin You, Ali H. Brivanlou & Eric D. Siggia (2019). A 3D model of a human being epiblast reveals BMP4-driven symmetry breaking. Nature Cell Biology 900/21: 900-910. DOI: 10,1038/s41556-019-0349-7
Source:
https://www.pharmazeutische-zeitung.de/modell-eines-menschlichen-embryos/
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Tuesday, 16 July 2019 11:32
3D Model of a human embryo Featured
Scientists from the Institute of Stem Cell Biology and Molecular Embryology at Rockefeller University in New York have made an important step in embryogenesis at a 3-D model of a human embryo.
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