The ‘next generation’ risk assessment uses new approach methodologies such as in vitro testing in cell lines or 3D organoids, combined with computational modelling. The methods are being developed in view of a higher relevance for humans, compared to tests in animals, and thus to ensure a better protection of human health. To provide additional guidance to safety assessors, the working group has issued a second report which describes examples of these novel methods with their strengths and limitations and illustrates how they
can be used in the cosmetic safety evaluation process.

The working group is part of the International Cooperation on Cosmetics Regulation (ICCR) which discusses common issues on cosmetics safety.

More information:
• Dent M. et al., “Principles underpinning the use of new methodologies in the risk assessment of cosmetic ingredients”, Computational Toxicology, 7 (2018), pp. 20-26.
doi: 10.1016/j.comtox.2018.06.001
This is the first article in the Computational Toxicology Special Issue on “In Silico Approaches for the Safety Assessment of Cosmetic-Related Substances”, guest-edited by a JRC scientist: https://www.sciencedirect.com/journal/computational-toxicology/special-issue/10P3BXBLJLK
• ICCR Report on Integrated Strategies for Safety Assessment of Cosmetic Ingredients: Part 2
• Report from the Commission to the European Parliament and the Council on the development, validation and legal acceptance of methods alternative to animal testing in the field of cosmetics (2015-2017). https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A52018DC0531

Source:
https://ec.europa.eu/jrc/en/science-update/next-generation-risk-assessment-cosmetics