Studies are often carried out on patients on the basis of poor preclinical research results from animal experiments, that could result in personal risk or would have no therapeutic benefit. Often the preclinical data collected are based on insufficient numbers of cases and are not reproducible, while negative results are not published.
The authors substantiate their results with case studies from the field of neurodegenerative diseases.
Original publication:
Yarborough M, Bredenoord A, D'Abramo F, Joyce NC, Kimmelman J, Ogbogu U, Sena E, Strech D & Dirnagl U. (2018). The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials. PLoS Biol. 16(6):e2006343. doi: 10,1371/journal.pbio.2006343.
Further points of criticism and information:
https://www.bihealth.org/en/notices/press-release-thinking-beyond-the-lab-call-for-improved-ethics-in-preclinical-research/
-
font size
decrease font size
increase font size
Thursday, 21 June 2018 14:21
Berlin: Call for more ethics in preclinical research Featured
In a press release published today, Professor Ulrich Dirnagl and Professor Daniel Strech from the Berlin Institute for Health Research (BIH) and from the Charité - Universitätsmedizin Berlin, together with their team of authors, appealed to scientists to accept a greater degree of responsibility and engage for an improved quality in preclinical research.
Dr. rer. nat.
Menschen für Tierrechte - Tierversuchsgegner Rheinland-Pfalz e.V.