Serotonin is a neurotransmitter that's partly responsible for feelings of happiness and for mood regulation in humans. This makes it a common target for antidepressants, which block serotonin from being reabsorbed by neurons after it has dispatched its signal, so more of it stays floating around the brain.
With the help of the new imaging technique, the therapeutic effect of anti-depressant can now be studies more intensively.
For more information:
http://news.mit.edu/2016/mapping-serotonin-dynamics-living-brain-1020