Using a cell culture with human tonsils and computer simulations, a European research team has deciphered a mechanism  which provide that dopamine, known as a neurotransmitter, influences the rate of signal cascade in B cells as well as the amout of available antibodies via a signal pathway in the germinal centers of the lymph nodes. The connection between dopamine and immune system does not exist in mice.

In vitro projects successfully completed

Tuesday, 18 July 2017 09:31

Two projects funded by Animal Free Research UK have been successfully completed. One is an in vitro model developed at the Queen Mary University of London, the other models with patient-specific neurinoma cells resp. meningioma tissue, constructed at Plymouth University.

A spanish scientist team plans to to print out patient's own bones and cartilages in three-dimensional form. With this tissues it should be possible to replace prostheses made of metal in future.

Today many diseases are treated with biopharmaceuticals, which are antibodies or other proteins. However, the mass production of these bio-drugs is often still done in mammalian cells. Using ciliates, a company has found a replacement for animal cells.

A scientist from the Karlsruhe Institute of Technology (KIT) estimates that it could take approximately 20 years before the animal experiments in the field of drug development can be replaced by multi-organ chips.

The European Reference Laboratory for alternatives to animal testing (EURL-ECVAM) has launched a validation study evaluating in vitro methods that are able to detect endocrine disruptive chemicals. In the validation study, 17 different in vitro methods are considered as candidates.

The American Institute for In Vitro Sciences (IIVS) has currently opened a laboratory for in vitro respiration studies. To start inhalation toxicology studies, IIVS received a in vitro exposure system. With the new device, the scientists want to investigate the effects of new cigarette products, such as the next generation heat-not-burn systems and e-cigarettes on human lung cells.

In a consultation paper on a reform of the Australian Chemicals Directive (National Industrial Chemicals Notification and Assessment Scheme, NICNAS) the Health Department of the Australian Government provides a ban for the production and marketing of "cosmetic chemicals" tested on animals in Australia from the first of July 2018 onwards. Cosmetic chemicals are those which are used solely for cosmetic purposes.

Animal-Free Research UK (formerly Dr. Hadwen Trust), the largest British foundation for animal-free medical research has invested 3.2 million pounds in research during the past 5 years and compiled a database of commercially available serum-free media, available as a resource for researchers around the world looking for suitable media. Goal is to replace the fetal calf sera as quick as possible. Together with the 3R-Centre Utrecht Life Sciences the database will be launched with a short opening ceremony in Utrecht.

During the annual meeting in Halle (Saale) the senate of the German Research Foundation (DFG) has decided to support a funding initiative to promote sequencing projects - and the associated expansion of the infrastructure at universities.