Researchers from the Max Planck Institute of Molecular Genetics have discovered that mutations occur in the iPS cell´s genome during re-programming of induced pluripotent stem cells (iPS). Mitochondria are particular affected by this.

Harmful reproductive toxicology experiments must no longer be performed on two animal generations.

Toxoplasma gondii can induce toxoplasmosis in humans. In a completed study funded by the Swiss Foundation 3r, scientists from the Pasteur Institute, Brussels, have developed a method by which they can test the virulence of Toxoplasma gondii in vitro.

The Clinical Research Laboratory of the Department of Thoracic and Cardiovascular Surgery at the University Hospital Tübingen and the Interfaculty Centre for Pharmacogenomics and Pharma Research are amongst this year’s prize winners in the German nationwide competition “365 Landmarks in the Land of Ideas”. The lab’s three award recipients, Prof. Dr. Albrecht Wendel (inventor of the innovative method), Prof. Dr. Hans Peter Wendel and Dr. Stefan Fennrich, were awarded the prize in recognition of their development of the in vitro pyrogen test “PyroDetect”.

The model combines two new technologies, tissue engineering using stem cells and impedance-based real-time cell monitoring using the xCELLigence Cardio instrument from ROCHE.

A development team at the nanomedical centre of the private non-profit company CSEM in Landquart, Switzerland, in collaboration with the Landquart company Fuchs Engineering GmbH, has developed a high-tech apparatus called “TestChest”. The apparatus allows simulations of unprecedented consistency and diversity for use in the field of cardiac and pulmonary medical training, and provides a replacement method for animal tests.

New and very promising scientific findings concerning toxicity tests on cells have been made by means of electrochemical measurements using electrochemical sensors with the help of IMOLA-IVD measurement systems and three-dimensional micro-tissue.

A Swedish surgery team has successfully implanted a trachea implant colonised with stem cells. The scientists did not require a donor organ, as they had also created an artificial scaffold, which was not the case in previous transplantations.

Researchers at the Fraunhofer Institute of Laser Technology (ILT) in Aachen, Germany, and other Fraunhofer institutes have used a special laser technique to create hybrid biomimetic matrices which can serve as basis for scaffold and implant structures on which cells can grow.

The California Institute for Regenerative Medicine (CIRM) has startet the fifth call with the title "Early Translational III Research Awards". Within the scope of a cooperation project, german researchers can also apply for the CIRM annoncement to receive promotional funding.  However, such researchers can also apply which develope in vitro models.