Friday, 22 July 2011 19:09

Cardiotoxicity: model for more exact research of drug induced heart problems Featured

The model combines two new technologies, tissue engineering using stem cells and impedance-based real-time cell monitoring using the xCELLigence Cardio instrument from ROCHE.

In the June issue of the Toxicological Sciences magazine, a research team headed by Dr. Kyle Kolaja of the ROCHE division Early and Investigative Safety, Nonclinical Safety, in Nutley, New Jersey (USA), reported on the development of a model for more exact research of drug induced heart problems.

Cardiomyocytes produced from pluripotent cells were treated with various active agents and the changes in impedance measured using Roche’s xCELLigence Cardio instrument. The results were comparable to those of an established low throughput in vitro method (measurement of electric field potential with microelectrode arrays).

Further information: http://www.roche.com
Source: http://www.pressebox.de