By now most quality controlls in stem cell research especially for regenerative medicine are based on mice studies. The new method “PluriTest“ enables the standardised verification of stem cell features in a fast growing number of human stem cell lines. PluriTest is based on a new bioinformatic algorithm which has been developed by Franz-Josef Müller and Bernhard Schuldt from the Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen.

For analysis they created the world wide greatest databasis of gene expression patterns of known human pluiripotent cell lines. Therefore a recognition algorithm of these patterns could be developed which can distinguish between pluripotent and non-pluripotent stem cell lines. This method is available for all researchers via internet under the address http://www.pluritest.org, so that they can analyse their new stem cell lines.

With the method the research group offers an alternative to stem cell investigations with lab mice. Furthermore scientists are able to achieve results more exactly.

Contact:

Dr. med. Franz-Josef Müller
Christian-Albrechts-Universität zu Kiel
Telefon: +49 431/99004169
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Dipl.-Math Bernhard Schult
Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen University
Telefon: +49 241/8099138
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Further information:
http://www.pluritest.org
http://www.systems-biology.com
http://www.nature.com/nmeth/index.html (DOI: 10.1038/nmeth.1580)