In mouse bioassays (MBA) approximately 300000 mice are used per year. Nowadays toxin profiles are identified by LC-MS/MS, a combination of liquid chromatographic methods (LC resp. HPLC) with mass spectrometry (MS). In several scientific opinions on issues related to differentz toxic groups, the EFSA (European Food and Savety Authority) stressed the meaning of the LC-MS/MS which is capable of determining multi-toxin groups und thier quantification. E.g. for determination of domoic acid, the use of HPLC-UV is standard method. LC-MS/MS allows to identify of each components of the regarded toxic group.
Read ECEAE press relaese http://www.eceae.org/
EFSA website http://www.efsa.europa.eu/
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Friday, 19 November 2010 15:38
Mouse bioassay for detection of toxins in shellfish close to an end
At the 17th of november, the EU-Commission has decided that the painful mouse-bioassay (MBA) for detection of algae toxins in shellfish has to be replaced within three years by chemico-/physical methods.
Dr. rer. nat.
Menschen für Tierrechte - Tierversuchsgegner Rheinland-Pfalz e.V.