Researchers at ETH Zurich have used cell cultures to find out more precisely why drugs do not work in all People in a same manner. The differences were analysed using systems biology, proteomics and metabolomics approaches.

 

 

With the help of a cholesterol-lowering drug, the research group led by Prof. Ruedi Aebersold of ETH Zurich was able to show that individual differences in effect cannot be attributed to one factor or a few factors. A large number of small molecular differences are responsible for this.

 

For their measurements the scientists used different human cell lines (HEK293, HeLa Kyoto, Huh7, and HepG2), exposed them to the cholesterol-lowering drug and measured proteins and metabolic products, which were produced differently in all cell lines.

 

The researchers concluded that the differences are generated by a combination of a variety of enzymes and biochemical reaction pathways.
 
The scientists fed their data into computer programs. Long-termin, they want to be able to predict patients' respond to a particular drug with computer models.

 

The Swiss researchers presented their investigations in the Journal Cell Systems.
Blattmann, P., Henriques, D., Zimmermann, M., Frommelt, F., Sauer, U., Saez-Rodriguez, J. & Aebersold, R. (2017). Systems pharmacology dissection of cholesterol regulation reveals determinants of large pharmacodynamics variability between cell lines.
Cell Systems 2017, doi: 10,1016/y.cels.2017.11.002

 

Read more here:
https://www.laborpraxis.vogel.de/warum-medikamente-bei-jedem-menschen-anders-wirken-koennen-a-692812/?cmp=nl-298&uuid=63E3C4F6-4639-461D-B148-07624636FB83