The document will deliver alternative approaches for standard information requirements while ensuring that tests on fish are only conducted as a last resort.
The strategy also proposes the further development of mechanistically-based replacement alternatives, as well as the need to revise existing test guidelines to reduce and refine testing on fish. Concerning bioaccumulation, efforts are encouraged to develop and apply in silico models such as quantitative structure-activity relationships and physiologically based toxicokinetic models, as well as the standardization of in vitro methods for hepatic metabolism in fish.
Read more: http://phys.org/news/2015-01-fish-chemicals-safety.html